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RNA purified for real time PCR analysis was converted to cDNA using the M-MLV RT (Promega) and subjected to real time PCR analysis using TaqMan universal PCR master mix (Roche) and indicated primers using ABI PRISM 7900GT sequencing detection system (Applied Biosystems).

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Grant Support: This work was funded in part by grants from the National Institutes of Health (NIH) R00CA126026-03 (SK) and 2PA50-CA090578-07 (DBC, DGT, BYY); the American Association for Cancer Research 07-40-12-COST (DBC); a Career Development Award by the American Society of Clinical Oncology Cancer Foundation CDA-15431 (DBC); and a Research Fellowship Award by the National Medical Research Council, Ministry of Health, Singapore (WY).

KRAS mutation did not correlate with either overall or progression-free survival.

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It is common for there to be some mild bleeding after a biopsy is taken, and this bleeding can last for a few days after the procedure.

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EGFR is a characteristic occurring in 10-15% of lung cancers in Europe, and studies have shown that these types of tumours are particularly sensitive to IRESSA.

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The following oncologists, radiation oncologists, and dermatologists took part in the First Italian Expert Opinions on skin toxicity management associated with cetuximab treatment in combination with chemotherapy or radiotherapy: Chiara Abeni (Brescia), Daniela Adua (Rome), Giovanni Baldino (Sassari), Maria Chiara Banzi (Reggio Emilia), Rossana Berardi (Ancona), Feisal Bunkheila (Bologna), Angela Buonadonna (Aviano-PN), Franco Calista (Campobasso), Giacomo Cartenì (Naples), Michele Caruso (Catania), Mario Giovanni Chilelli (Viterbo), Domenico Cristiano Corsi (Rome), Renzo Corvò (Genoa), Agostina De Stefani (Treviglio-BG), Nerina Denaro (Messina), Concetta Di Blasi (Catania), Antonella Ferro (Trento), Giuseppe Fornarini (Genoa), Mario Franchini (Turin), Fabio Fulfaro (Palermo), Geppino Genua (Ariano Irpino-AV), Francesco Giuliani (Bari), Gabriele Luppi (Modena), Elena Magni (Milan), Andrea Mancuso (Rome), Mariangela Manzoni (Pavia), Gianluca Masi (Pisa), Cataldo Mastromauro (Mestre-VE), Renzo Mazzarotto (Bologna), Anna Mercanti (Verona), Mauro Minelli (Rome), Miriam Paris (Biella), Veronica Parolin (Verona), Ida Pavese (Rome), Lorenzo Pavesi (Pavia), Nicola Personeni (Rozzano-MI), Patrizia Racca (Turin), Monica Rampino (Turin), Enrico Ricevuto (Rome), Fabiola Lorena Rojas Llimpe (Bologna), Graziana Ronzino (Lecce), Antonino Savarino (Canicattì-AG), and Alessandro Tuzi (Rome).

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