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What is the best time of day to take metformin? Metformin alone: At first, 500 milligrams (mg) two times a day taken with the morning and evening meals, or 850 mg a day taken with the morning meal. Your doctor may increase your dose if needed until your blood sugar is controlled.
Is metformin hard on the kidneys? Background: Impaired renal function can lead to the accumulation of metformin, and elevated concentrations of metformin have been associated with lactic acidosis. Conclusions: Metformin may have an adverse effect on renal function in patients with type 2 DM and moderate CKD.

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